Journal: International Journal of Molecular Sciences
Article Title: Deletion of Trpm4 Alters the Function of the Na v 1.5 Channel in Murine Cardiac Myocytes
doi: 10.3390/ijms22073401
Figure Lengend Snippet: Intracardiac electrocardiogram recordings on WT and Trpm4 −/− explanted hearts. ( A ) Representative pseudo (P.ECG) and intracardiac (IC.ECG) ECG trace from a WT heart. A and V respectively represent atrial and ventricle signals from the intracardiac catheter recorded in different electrode channels (CH 1-7). Conduction delays either between the atria and ventricle (AV delay, CH 6-5) or intraventricular (IV delay, CH 4-1) were measured as the time delay between respective channel signals. Representative trace showing signal derivatives from CH 1 and 4 to measure IV delay ( B ). Average AV delay ( C ) and IV delay ( D ), compared between the genotypes (WT: circle, black and Trpm4 −/− : square, red). Note: N = 6, #: p < 0.05, WT vs. Trpm4 −/− ; ns = not significant.
Article Snippet: The surface lead II ECG signal was acquired using limb needle electrodes (MLA1213, AD Instruments, Sydney, Australia).
Techniques: